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KMID : 1189420110240010078
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2011 Volume.24 No. 1 p.78 ~ p.85
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The effects of Hyunggaeyungyo-tang of suppression of iNOS production on RAW 264.7cell
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Park Jung-Hoon
Kim Jong-Che
Hong Seung-Ug
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Abstract
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Background and Objectives :The aim of this study was to investigate anti-inflammatory and anti-oxidant effects of Hyunggaeyungyo-tang(HYT) on RAW 264.7 cells.
Materials and Methods:Two types of experiments were implemented for this study: first, the experiment to study the anti-oxidant effect of HYT using riboflavin; second, in vitro experiment to investigate the suppression of NF-B activation using RAW 264.7 cells (IB kinase and induce nitric oxide synthase mRNA expression)
Results: 1. The anti-oxidant effects of HYT was dose-dependantly increased. 2. The RAW 264.7cells were treated with LPS for 1 hours prior to the addition of indicated concentrations(0.4,-1.0mg/) of HYT, and the cells were further incubated for 24 hours. The LPS-induced IKK & iNOS mRNA expression were dose-dependantly decreased in HYT treated RAW 264.7cells.
Conslusion: The results suggest that HYT is significantly effective in the treatment of inflammation through the suppression of NF-B activation and iNOS production.
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KEYWORD
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Hyunggaeyungyo-tang, anti-inflammation, NF-xB, iNOS
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